Welcome to the Spratt Lab! We are located in the Carlson School of Chemistry & Biochemistry at Clark University.  Our group currently has two research foci:

1. Understanding enzyme catalysis and protein-protein interactions for enzymes involved in the ubiquitylation-signaling pathway

2. Deciphering the mechanism of homeodomain transcription factor-DNA recognition and specificity.

Working at the interface of physical biochemistry and chemical biology, our group uses biochemical and biophysical techniques including solution nuclear magnetic resonance (NMR) spectroscopy and isothermal titration calorimetry (ITC) to understand how proteins carry out their functions at the molecular level.

This website will give you some background on our research program at Clark University, group members (current and past), our publications, the list of the instruments in our well-equipped lab for routine protein chemistry work, lab news, and links to websites we routinely use to aid in our research endeavors.

*** Undergraduate students interested in volunteering and getting involved in research are encouraged to send an email to dspratt@clarku.edu ***

Recent News

August 24th, 2020 – Don’s commentary on “Five Practical Tips for a Successful Career in STEM” was published by Diverse: Issues in Higher Education.  Check it out!