Welcome to the Spratt Lab! We are located in the Carlson School of Chemistry & Biochemistry at Clark University. Our group is interested in understanding enzyme catalysis and protein-protein interactions for enzymes involved in the ubiquitylation-signaling pathway. Working at the interface of physical biochemistry and chemical biology, our group uses biochemical and biophysical techniques including solution nuclear magnetic resonance (NMR) spectroscopy to understand how HECT E3 ubiquitin ligases attach ubiquitin or ubiquitin-like proteins to a substrate protein.
This website will give you some background on our research program at Clark University, group members (current and past), our publications, a list of the instruments in our well-equipped lab for routine protein chemistry work, lab news, and links to websites we routinely use to aid in our research endeavors.
*** We are looking for motivated graduate students to join our research team. Interested students are encouraged to send their resume/CV, a brief research statement, and contact information for three references to firstname.lastname@example.org ***
*** Undergraduate students interested in volunteering and getting involved in research are encouraged to send an email to email@example.com ***
January 17th, 2019 – A news story on Don’s “LEEPing in to a Science Career” was highlighted on ClarkNOW. This vocational course is focused on helping science majors learn how to successfully navigate the job market and secure a scientific job after completing their studies at Clark. Check it out!
December 31st, 2018 – Don was interviewed by Science Magazine for “Your Practical Guide to Basic Laboratory Techniques“. Check it out!
December 6th, 2018 – Justine’s 3D printing project that she completed for Dr. Nathan Ahlgren’s “Viruses: Friends or Foes” course was highlighted on ClarkNOW. Very cool! Well done, Justine!
September 18th, 2018 – Steve and Roela’s paper titled “1H, 13C, and 15N resonance assignments of the C-terminal lobe of the human HECT E3 ubiquitin ligase ITCH” was published in Biomolecular NMR Assignments. Check it out!
August 15th, 2018 – Congratulations Noah on successfully defending your M.S. thesis today! Way to go!
July 9-12th, 2018 – Don gave a Young Investigator Talk and Lara, Emilie, and Noah gave poster presentations at the Protein Society’s 32nd Annual Symposium in Boston, MA.
June 29th, 2018 – Congratulations Emilie on successfully defending your M.S. thesis today! Great job!
June 19th, 2018 – Congratulations Rachel on successfully defending your M.S. thesis today! Well done!
June 14th, 2018 – The Clark University Summer Undergraduate Research Program, which includes Young Sun, Kayla, Chloe, Rylee, Emily, and Justine, was highlighted on Research Matters at Clark!
June 3-6th, 2018 – Don presented our recent findings on HERC6 at The Ubiquitin System: Function, Physiology and its Role in Disease Conference in Nassau, Bahamas.
April 25th, 2018 – Undergraduate research by Honors and Directed Study students in our lab was presented at the 28th Annual Academic Spree Day at Clark University!
April 20th, 2018 – Diana successfully defended her Honors thesis today. Diana was also awarded the Biochemistry Award from the American Institute of Chemists. Congratulations, Diana!
April 18th, 2018 – Emilie, Lara, Rachel, and Noah presented their research at the Graduate Multidisciplinary Conference at Clark University. Well done!
March 13th, 2018 – A news story about our recent R15 AREA grant from the NIH to study the HECT E3 ligases was highlighted on ResearchMatters at Clark!