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Current laboratory members (left to right): Bethany Lee (BCMB, Class of 2020), Amy Zheng (PhD student), Merc Kemeh (PhD student), Dr. Noel Lazo, Henrique Lemos-Brito (BCMB, Class of 2020), Timothy Soldano (BCMB, Class of 2020),  Ibrahim Ozgenc (BCMB, Class of 2020), and Saadman Islam (BCMB, BA/MS expected in 2020). 

OUR MAIN AREA OF INTEREST IS  PROTEIN MISFOLDING AND SELF-ASSEMBLY ASSOCIATED WITH DISEASE

Proteins of interest:
Amyloid proteins associated with amyloidoses including the islet amyloid polypeptide in type 2 diabetes, the amyloid-β protein in Alzheimer’s disease, and lysozyme in systemic amyloidosis; keratins and collagens in the skin blistering disease called epidermolysis bullosa.

Methods:
We use a variety of biophysical and biochemical techniques including nuclear magnetic resonance, circular dichroism, limited proteolysis/mass spectrometry, electron microscopy and molecular modeling to probe the folding and self-assembly of proteins associated with disease.

LAB NEWS…

Fall 2021:

  • Our paper co-first authored by Amy, Mike and Bethany on the differential effects of polyphenols on insulin proteolysis by the insulin-degrading enzyme is now in Antioxidants 2021 10(9), 1342.  

Summer 2021:

  • Bethany Lee [BCMB (Class of 2020)] successfully defended her MS thesis!  Congratulations, Bethany!  All the best in your junior scientist position at AbbVie Pharmaceuticals!