{"id":76,"date":"2011-12-08T19:01:38","date_gmt":"2011-12-08T19:01:38","guid":{"rendered":"https:\/\/wordpress.clarku.edu\/nmeyer\/?page_id=76"},"modified":"2012-08-20T14:01:34","modified_gmt":"2012-08-20T14:01:34","slug":"brain-development","status":"publish","type":"page","link":"https:\/\/wordpress.clarku.edu\/nmeyer\/research\/brain-development\/","title":{"rendered":"Brain Development"},"content":{"rendered":"<p><em>C. teleta<\/em> is a powerful system for studying developmental biology in an evolutionary context.\u00a0 A key step during <a href=\"https:\/\/wordpress.clarku.edu\/wp-content\/uploads\/sites\/59\/2011\/11\/2ST6e_ant4c2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-medium wp-image-103\" src=\"https:\/\/wordpress.clarku.edu\/wp-content\/uploads\/sites\/59\/2011\/11\/2ST6e_ant4c2-300x300.jpg\" alt=\"\" width=\"300\" height=\"300\" srcset=\"https:\/\/wordpress.clarku.edu\/nmeyer\/wp-content\/uploads\/sites\/59\/2011\/11\/2ST6e_ant4c2-300x300.jpg 300w, https:\/\/wordpress.clarku.edu\/nmeyer\/wp-content\/uploads\/sites\/59\/2011\/11\/2ST6e_ant4c2-150x150.jpg 150w, https:\/\/wordpress.clarku.edu\/nmeyer\/wp-content\/uploads\/sites\/59\/2011\/11\/2ST6e_ant4c2.jpg 984w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a>central nervous system development in arthropods and vertebrates is specifying the fate of neural precursor cells (NPCs), which generate the brain and nerve cord.\u00a0\u00a0<a href=\"https:\/\/wordpress.clarku.edu\/wp-content\/uploads\/sites\/59\/2011\/11\/MeyerSeaver-2009.pdf\" target=\"_blank\">Based on previous work<\/a>,\u00a0the cellular mechanisms of <em>C. teleta<\/em> brain development appear similar to those found in the development of the arthropod CNS. However, preliminary functional analyses of a proneural homolog in <em>C. teleta<\/em> (<em>CapI-ash1<\/em>) suggest a function that is more similar to proneural gene function during vertebrate neurogenesis.\u00a0 My lab\u00a0employs several approaches to characterize the cellular and molecular aspects driving NPC fate specification during central nervous system development in <em>C. teleta, <\/em>including\u00a0include high resolution imaging, gene expression analysis, functional analysis, and bioinformatics approaches, which are facilitated by a sequenced (8x coverage) <em>C. teleta<\/em> genome.<\/p>\n<p>To further refine\u00a0our\u00a0model of brain development in <em>C. teleta<\/em>, we are currently developing methods for characterizing NPC behavior in real time, which\u00a0will be combined with misexpression of proteins in the anterior ectoderm and functional analyses of neurogenic candidates.\u00a0 These techniques will be used to address questions such as whether or not a single NPC undergoes a stem-cell like mode of division in the surface to generate multiple neurons, or if NPCs undergo any additional divisions after they are internalized.\u00a0 Furthermore, these techniques\u00a0can be combined with functional analyses to determine patterns\u00a0of cell ingression, proliferation, and NPC fate specification in treated animals.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>C. teleta is a powerful system for studying developmental biology in an evolutionary context.\u00a0 A key step during central nervous system development in arthropods and vertebrates is specifying the fate of neural precursor cells (NPCs), which generate the brain and nerve cord.\u00a0\u00a0Based on previous work,\u00a0the cellular mechanisms of C. teleta &#8230; <a class=\"continue-reading-link\" href=\"https:\/\/wordpress.clarku.edu\/nmeyer\/research\/brain-development\/\"> Continue reading<\/a><\/p>\n","protected":false},"author":93,"featured_media":254,"parent":7,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ngg_post_thumbnail":0,"footnotes":""},"class_list":["post-76","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/wordpress.clarku.edu\/nmeyer\/wp-json\/wp\/v2\/pages\/76","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wordpress.clarku.edu\/nmeyer\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/wordpress.clarku.edu\/nmeyer\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/wordpress.clarku.edu\/nmeyer\/wp-json\/wp\/v2\/users\/93"}],"replies":[{"embeddable":true,"href":"https:\/\/wordpress.clarku.edu\/nmeyer\/wp-json\/wp\/v2\/comments?post=76"}],"version-history":[{"count":0,"href":"https:\/\/wordpress.clarku.edu\/nmeyer\/wp-json\/wp\/v2\/pages\/76\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/wordpress.clarku.edu\/nmeyer\/wp-json\/wp\/v2\/pages\/7"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/wordpress.clarku.edu\/nmeyer\/wp-json\/wp\/v2\/media\/254"}],"wp:attachment":[{"href":"https:\/\/wordpress.clarku.edu\/nmeyer\/wp-json\/wp\/v2\/media?parent=76"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}