{"id":17,"date":"2012-08-15T17:57:59","date_gmt":"2012-08-15T17:57:59","guid":{"rendered":"https:\/\/wordpress.clarku.edu\/nlazo\/?page_id=17"},"modified":"2024-11-12T16:42:10","modified_gmt":"2024-11-12T16:42:10","slug":"publications","status":"publish","type":"page","link":"https:\/\/wordpress.clarku.edu\/nlazo\/publications\/","title":{"rendered":"Recent Publications"},"content":{"rendered":"

Kemeh MM and Lazo ND. Highly Toxic A\u03b2 Begets More A\u03b2. Neural Regeneration Research<\/em> 2024, 19(9), 1871-1872. This work was supported by a grant from the National Institute on Aging (R15AG055043) and by the Lise Ann and Leo E. Beavers II endowment to Clark University.<\/p>\n

Kemeh MM and Lazo ND. Modulation of the Activity of the Insulin-degrading Enzyme by A\u03b2 Peptides. ACS Chemical Neuroscience<\/em> 2023, 14, 2935-2943. This work was supported by a grant from the National Institute on Aging (R15AG055043) and by the Lise Ann and Leo E. Beavers II endowment to Clark University.<\/p>\n

Zheng Q, Lee B, Kebede MT, Ivancic VA, Kemeh MM, Lemos Brito H, Spratt DE and Lazo ND. Exchange Broadening Underlies the Enhancement of IDE-Dependent Degradation of Insulin by Anionic Membranes. ACS Omega<\/em> 2022, 7, 24757-24765. This work was supported by a grant from the National Institute on Aging (R15AG055043).<\/p>\n

Zheng Q, Kebede MT, Lee B, Krasinski CA, Islam S, Wurfl LA, Kemeh MM, Ivancic VA, Jakobsche CE, Spratt DE and Lazo ND. Differential Effects of Polyphenols on Insulin Proteolysis by the Insulin-degrading Enzyme. Antioxidants<\/em> 2021, 10(1342), 1-11. This work was supported by a grant from the National Institute on Aging (R15AG055043).<\/p>\n

Bocach DB, Jones KL, Bell JM, Zheng Q, Lazo ND, Smith-Carpenter JE, Alper BJ. Ghrelin Proteolysis by Insulin-degrading Enzyme. bioRxiv <\/em>2021.  <\/span>doi:<\/span> 10.1101\/2021.06.10.447714. This work was partly supported by a grant from the National Institute on Aging (R15AG055043).<\/span><\/p>\n

Zheng Q, Carty SN and Lazo ND. Helix Dipole and Membrane Electrostatics Delineate Conformational Transitions in the Self-Assembly of Amyloidogenic Peptides. Langmuir<\/em> 2020, 86, 8389-8397. This work was supported by a grant from the National Institute on Aging (R15AG055043) and by the Lise Ann and Leo E. Beavers II endowment to Clark University.<\/p>\n

DOI: <\/span>10.1021\/acs.langmuir.0c00723<\/a><\/span><\/p>\n

Zheng Q, Kebede MK, Kemeh MM, Islam S, Lee B, Bleck SD, Wurfl LA and Lazo ND. Inhibition of the Self-Assembly of A\u03b2 and of Tau by Polyphenols: Mechanistic Studies. Molecules <\/em>2019, 24 (2316), 1-20. This work was supported by a grant from the National Institute on Aging (R15AG055043).<\/p>\n

DOI: 10.3390\/molecules24122316<\/a><\/p>\n

Ivancic VA, Krasinski CA, Zheng Q, Meservier RJ, Spratt DE and Lazo ND. Enzyme kinetics from circular dichroism of insulin reveals mechanistic insights into the regulation of insulin-degrading enzyme. Bioscience Reports<\/em> 2018, 38(6), 1-10. This work was supported by a grant from the National Institute on Aging (R15AG055043).<\/p>\n

PMID:<\/span> <\/span>30305381 <\/span>PMCID: PMC6239264<\/a> <\/span>DOI: 10.1042\/BSR20181416<\/a><\/span><\/p>\n

Krasinski CA, Ivancic VA, Zheng Q, Spratt DE and Lazo ND. Resveratrol sustains insulin-degrading enzyme activity towards A\u00df42. ACS Omega<\/em> 2018, 3(10), 13275-13282. This work was supported by a grant from the National Institute on Aging (R15AG055043).<\/p>\n

PMID:<\/span> <\/span>30411033 <\/span>PMCID: PMC6210067<\/a> <\/span>DOI: 10.1021\/acsomega.8b01913<\/a><\/span><\/p>\n

Krasinski CA, Zheng Q, Ivancic VA, Spratt DE and Lazo ND. The longest amyloid-\u00df precursor protein intracellular domain produced with A\u00df42 forms \u00df-sheet-containing monomers that self-assemble and are proteolyzed by insulin-degrading enzyme. ACS Chemical Neuroscience.<\/em> 2018, 9, 2892-2897. This work was supported by a grant from the National Institute on Aging (R15AG055043).<\/p>\n

PMID:<\/span> <\/span>30067897 <\/span>DOI: 10.1021\/acschemneuro.8b00305<\/a><\/span><\/p>\n

Zheng Q and Lazo ND. Mechanistic studies of the inhibition of insulin fibril formation by rosmarinic acid. Journal of Physical Chemistry B<\/em> 2018, 122, 2323-2331. This work was supported in part by a grant from the Lise Ann and Leo E. Beavers II endowment to Clark University. <\/p>\n

PMID:<\/span> <\/span>29401384 <\/span>DOI: 10.1021\/acs.jpcb.8b00689<\/a><\/span><\/p>\n

Fontaine DFA, Ivancic VA, Reardon MB, Lazo ND, Jakobsche CE. A versatile platform for adding functional properties to amyloid fibrils. Organic Biomolecular Chemistry<\/em> 2017, 15, 8023-8027. <\/p>\n

PMID:<\/span> <\/span>28930349 <\/span>DOI: 10.1039\/c7ob02042b<\/a><\/span><\/p>\n

Ivancic VA, Ekayanake O and Lazo ND. Binding mode of thioflavin T on the surface of amyloid fibrils. ChemPhysChem<\/i> 2016, 17, 2461-2464.<\/p>\n

PMID:<\/span> <\/span>27165642 <\/span>DOI: 10.1002\/cphc.201600246<\/a><\/span><\/p>\n

Selmani V, Robbins KJ, Ivancic VA and Lazo ND. K114 (trans, trans)-bromo-2,5-bis (4-hydroxystyryl)benzene is an efficient detector of cationic amyloid fibrils. Protein<\/em> Science<\/em> 2015, 24, 420-425.<\/p>\n

PMID:<\/span> <\/span>25524064 <\/span>PMCID: PMC4353367<\/a> <\/span>DOI: 10.1002\/pro.2620<\/a><\/span><\/p>\n

Robbins KJ, Liu G, Selmani V and Lazo ND. Conformational analysis of thioflavin T bound to the surface of amyloid fibrils. Langmuir<\/em> 2012, 28, 16490-16495.<\/p>\n

PMID:<\/span> <\/span>23151310 <\/span>DOI: 10.1021\/la303677t<\/a><\/span><\/p>\n

Liu G, Gaines JC, Robbins KJ and Lazo ND. Kinetic profile of amyloid formation in the presence of an aromatic inhibitor by nuclear magnetic resonance. ACS Medicinal Chemistry<\/em> Letters<\/em> 2012, 3, 856-859.<\/p>\n

PMID:<\/span> <\/span>24900390 <\/span>PMCID: PMC4025671<\/a> <\/span>DOI: 10.1021\/ml300147m<\/a><\/span><\/p>\n

Liu G, Robbins KJ, Sparks S, Selmani V, Bilides K and Lazo ND. Helix dipole effects in peptide self-assembly to amyloid. Biochemistry<\/em> 2012, 51, 4167-4174.<\/p>\n

PMID:<\/span> <\/span>22559877 <\/span>DOI: 10.1021\/bi3001616<\/a><\/span><\/p>\n

Sparks S, Liu G, Robbins KJ and Lazo ND. Curcumin modulates the self-assembly of the islet amyloid polypeptide by disassembling \u03b1-helix. Biochemical Biophysical Research Communications<\/em> 2012, 422, 551-555.<\/p>\n

PMID:<\/span> <\/span>22579683 <\/span>DOI: 10.1016\/j.bbrc.2012.05.013<\/a><\/span><\/p>\n

Robbins KJ, Liu G, Lin G and Lazo ND. Detection of strongly bound thioflavin T species in amyloid fibrils by ligand-detected 1<\/sup>H NMR. Journal of Physical Chemistry Letters<\/em> 2011, 2, 735-740.<\/p>\n

Liu G, Prabhakar A, Aucoin D, Simon M, Sparks S, Robbins KJ, Sheen, Petty SA and Lazo ND. Mechanistic studies of peptide self-assembly: Transient \u03b1-helices to stable \u03b2-sheets. Journal of the Americal Chemical Society<\/em> 2010, 132, 18223-18232.<\/p>\n

PMID:<\/span> <\/span>21138275 <\/span>DOI: 10.1021\/ja1069882<\/a><\/span><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Kemeh MM and Lazo ND. Highly Toxic A\u03b2 Begets More A\u03b2. Neural Regeneration Research 2024, 19(9), 1871-1872. This work was supported by a grant from the National Institute on Aging (R15AG055043) and by the Lise Ann and Leo E. Beavers … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":201,"featured_media":0,"parent":0,"menu_order":300,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ngg_post_thumbnail":0,"footnotes":""},"class_list":["post-17","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/wordpress.clarku.edu\/nlazo\/wp-json\/wp\/v2\/pages\/17","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wordpress.clarku.edu\/nlazo\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/wordpress.clarku.edu\/nlazo\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/wordpress.clarku.edu\/nlazo\/wp-json\/wp\/v2\/users\/201"}],"replies":[{"embeddable":true,"href":"https:\/\/wordpress.clarku.edu\/nlazo\/wp-json\/wp\/v2\/comments?post=17"}],"version-history":[{"count":0,"href":"https:\/\/wordpress.clarku.edu\/nlazo\/wp-json\/wp\/v2\/pages\/17\/revisions"}],"wp:attachment":[{"href":"https:\/\/wordpress.clarku.edu\/nlazo\/wp-json\/wp\/v2\/media?parent=17"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}