{"id":471,"date":"2025-10-17T15:48:38","date_gmt":"2025-10-17T15:48:38","guid":{"rendered":"https:\/\/wordpress.clarku.edu\/jdresch\/?page_id=471"},"modified":"2025-10-20T20:07:06","modified_gmt":"2025-10-20T20:07:06","slug":"coaching-enhancers-how-do-they-work-together","status":"publish","type":"page","link":"https:\/\/wordpress.clarku.edu\/jdresch\/?page_id=471","title":{"rendered":"Coacting Enhancers: How do they work together?"},"content":{"rendered":"<div>\n<p class=\"p1\">Recently, coacting (or shadow) enhancers have been identified at a growing number of critical developmental genes in <i>Drosophila<\/i>and other species.&nbsp; A key question in modern developmental biology is how the architecture of multiple functional TF binding sites is organized in these coacting enhancers to control their precise output.&nbsp; The goal of this project is to use mathematical modeling approaches to decipher the mechanisms at play within individual enhancers, as well as to gain a deeper understanding of the molecular mechanisms behind interactions between the enhancers.&nbsp; We are employing a number of different mathematical frameworks to try to answer the underlying question of why and how coacting enhancers work together to ensure robust gene expression during <i>Drosophila<\/i> development.<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-467\" src=\"https:\/\/wordpress.clarku.edu\/jdresch\/wp-content\/uploads\/sites\/383\/2025\/10\/Shadow-scaled.jpg\" alt=\"\" width=\"2560\" height=\"2164\" srcset=\"https:\/\/wordpress.clarku.edu\/jdresch\/wp-content\/uploads\/sites\/383\/2025\/10\/Shadow-scaled.jpg 2560w, https:\/\/wordpress.clarku.edu\/jdresch\/wp-content\/uploads\/sites\/383\/2025\/10\/Shadow-300x254.jpg 300w, https:\/\/wordpress.clarku.edu\/jdresch\/wp-content\/uploads\/sites\/383\/2025\/10\/Shadow-1024x866.jpg 1024w, https:\/\/wordpress.clarku.edu\/jdresch\/wp-content\/uploads\/sites\/383\/2025\/10\/Shadow-1000x845.jpg 1000w, https:\/\/wordpress.clarku.edu\/jdresch\/wp-content\/uploads\/sites\/383\/2025\/10\/Shadow-768x649.jpg 768w, https:\/\/wordpress.clarku.edu\/jdresch\/wp-content\/uploads\/sites\/383\/2025\/10\/Shadow-1536x1299.jpg 1536w, https:\/\/wordpress.clarku.edu\/jdresch\/wp-content\/uploads\/sites\/383\/2025\/10\/Shadow-2048x1731.jpg 2048w\" sizes=\"auto, (max-width: 2560px) 100vw, 2560px\" \/><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Recently, coacting (or shadow) enhancers have been identified at a growing number of critical developmental genes in Drosophilaand other species.&nbsp; A key question in modern developmental biology is how the architecture of multiple functional TF binding sites is organized in &hellip; <a href=\"https:\/\/wordpress.clarku.edu\/jdresch\/?page_id=471\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":571,"featured_media":0,"parent":29,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ngg_post_thumbnail":0,"footnotes":""},"class_list":["post-471","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/wordpress.clarku.edu\/jdresch\/index.php?rest_route=\/wp\/v2\/pages\/471","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wordpress.clarku.edu\/jdresch\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/wordpress.clarku.edu\/jdresch\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/wordpress.clarku.edu\/jdresch\/index.php?rest_route=\/wp\/v2\/users\/571"}],"replies":[{"embeddable":true,"href":"https:\/\/wordpress.clarku.edu\/jdresch\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=471"}],"version-history":[{"count":0,"href":"https:\/\/wordpress.clarku.edu\/jdresch\/index.php?rest_route=\/wp\/v2\/pages\/471\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/wordpress.clarku.edu\/jdresch\/index.php?rest_route=\/wp\/v2\/pages\/29"}],"wp:attachment":[{"href":"https:\/\/wordpress.clarku.edu\/jdresch\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=471"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}