WELCOME TO THE LAZO LAB!
OUR MAIN AREA OF INTEREST IS PROTEIN MISFOLDING AND SELF-ASSEMBLY ASSOCIATED WITH DISEASE
Proteins of interest:
Amyloid proteins associated with amyloidoses including the islet amyloid polypeptide in type 2 diabetes, the amyloid-β protein in Alzheimer’s disease, and lysozyme in systemic amyloidosis; keratins and collagens in the skin blistering disease called epidermolysis bullosa.
We use a variety of biophysical and biochemical techniques including nuclear magnetic resonance, circular dichroism, limited proteolysis/mass spectrometry, electron microscopy and molecular modeling to probe the folding and self-assembly of proteins associated with disease.
Our work on the amyloid-β protein is funded by an Academic Research Enhancement Award from the National Institute on Aging of the National Institutes of Health (R15 AG055043, 2018-2021).
February 5, 2018:
Amy’s paper on the mechanistic studies of the inhibition of insulin fibrillation is now out in the Journal of Physical Chemistry B.