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OUR MAIN AREA OF INTEREST IS ON THE BIOPHYSICAL CHEMISTRY OF PROTEIN MISFOLDING AND SELF-ASSEMBLY IN DISEASE.

Proteins of interest:
Amyloid proteins associated with amyloidoses including the islet amyloid polypeptide in type 2 diabetes, the amyloid-β protein in Alzheimer’s disease, and lysozyme in systemic amyloidosis; keratins and collagens in the skin blistering disease called epidermolysis bullosa.

Biophysical methods:
We use a variety of biophysical and biochemical techniques including nuclear magnetic resonance, circular dichroism, limited proteolysis/mass spectrometry, and electron microscopy to probe the folding and self-assembly of proteins associated with disease.

 

 LAB NEWS…

TravisJuly 2015: Congratulations to Travis Stutzer (BA in Biochemistry and Molecular Biology, Class of 2014) for successfully defending his MS thesis on the self-assembly of pyroglutamylated amyloid-β protein!

 

 

 

FB_IMG_1441718977796-1May 2015: Congratulations to Oshini Ekayanake for obtaining her BA in Biochemistry and Molecular Biology! She is now at the University of Delaware to obtain a PhD in biochemistry. During her senior year, Oshini investigated the self-assembly of lysozyme.

 

 

 

LinaMarch 2015: Congratulations to Lina Kroehling (BA in Biochemistry and Molecular Biology, Class of 2014) for successfully defending her MS thesis on the membrane-mediated self-assembly of islet amyloid polypeptide which is associated with the death of pancreatic beta cells in type 2 diabetes.  Part of her work has been submitted for publication.