This article presents a new family of bifunctional molecules that we designed and synthesized. These molecular tools bind to the active-site quinones in a family of amine oxidases and enable visualization of active enzymes by western blotting or fluorescence.
*A. A. Burke, *L. Barrows, *M. J. Solares, *A. D. Wall, C. E. Jakobsche

This article describes a molecular design concept that enables the creation of various molecular tools that manipulate amyloid fibrils at the molecular level. This work opens the door to future directions in molecular medicine, nanotechnology, and chemical biology applications.
*D. F. A. Fontaine, *V. A. Ivancic, *M. B. Reardon, N. D. Lazo, C. E. Jakobsche

This invited review article surveys a number of methods for synthesizing the unnatural amino acid 6-hydroxynorleucine along with a number of interesting synthetic target molecules that have been made using this compound.
*N. S. MacArthur, C. E. Jakobsche

This study analyzes four chemical motifs as irreversible inhibitors of an enzyme that is relevant to cancer metastasis. Detailed studies of the kinetics of inhibition were performed to determine which of the structures is most promising for further development.
*A. A. Burke, *E. S. Severson, *S. Mool, *M. J. Solares Bucaro, F. T. Greenaway, C. E. Jakobsche

This collaborative study explores the solid-solid, paramagnetic-diamagnetic phase transition in a family of stable organic radicals. Our group’s contribution was to synthesize the target compound and collect experimental data on its phase transition to support the theoretical and computational predictions made by Professor Novoa’s group.
S. Vela, *M. B. Reardon, C. E. Jakobsche, M. M. Turnbull, J. Ribas-Arino, J. J. Novoa

This study uses a combination of kinetics experiments and computational analyses to study how subtle changes to an electrophile’s structure can influence its reactivity despite being far from the reactive site. The results of these studies suggest that an interesting orbital mixing interaction contributes to these effects.
*M. B. Reardon, *M. Xu, *Q. Tan, *P. G. Baumgartel, *D. J. Augur, S. Huo, C. E. Jakobsche

This study describes an approach to synthesizing trans-bicyclic structures by a selective intramolecular alkylation of a cyclopentanone intermediate.
*M. B. Reardon, *B. C. Yasgur, C. E. Jakobsche

This study describes an efficient synthetic sequence to convert L-Lysine into L-6-hydroxynorleucine, which is a broadly useful building block molecule for synthesizing numerous biologically active compounds.
*B. G. McCarthy, *N. S. MacArthur, C. E. Jakobsche

This study describes the development of a reaction sequence to transform amine functional groups into alcohols.
*N. S. MacArthur, *L. Wang, *B. G. McCarthy, C. E. Jakobsche

This study describes a new synthetic strategy to construct a difficult-to-make ketone while controlling the site of reaction and the stereochemistry of the product.
*M. B. Reardon, *G. W. Carlson, C. E. Jakobsche

This review, which resulted from a directed readings course, highlights some examples of how meditation can affect the body at the molecular level and how these molecular changes relate to physiological changes in the body.
*W. C. Daube, C. E. Jakobsche

This study compares the abilities of various small-molecule motifs to bind antibodies found in non-immunized human serum and to utilize those antibodies to direct cytotoxic immune responses against cancer cells.
C. E. Jakobsche, C. G. Parker, R. N. Tao, M. D. Kolesnikova, E. F. Douglass Jr., D. A. Spiegel

This study describes a strategy to use synthetic organic molecules to direct components of the normal human immune system to identify and destroy human cancer cells.
C. E. Jakobsche, P. J. McEnaney, A. X. Zhang, D. A. Spiegel

This study describes a newly identified interaction between molecular orbitals that influences the conformation of proline-containing molecules.
C. E. Jakobsche, A. Choudhary, S. J. Miller, R. T. Raines

This study describes the synthesis and use of alkenes and fluoroalkenes to study how an epoxidation catalyst uses its amides to interact with its substrates.
C. E. Jakobsche, G. Peris, S. J. Miller

This study describes two new transition-metal-catalyzed reductions.
A. Voutchkova, D. Gnanamgari, C. E. Jakobsche, C. Butler, S. J. Miller, J. Parr, R. H. Crabtree

This study describes a new catalytic cycle for performing epoxidation reactions and its use for forming enentioenriched epoxides.
G. Peris, C. E. Jakobsche, S. J. Miller

This study describes the synthesis of several organic molecules that are non-natural analogues of medicinally interesting naturally occurring molecules.
J. H. Markgraf, A. D. Dowst, L. A. Hensley, C. E. Jakobsche, C. J. Kaltner, P. J. Webb, P.